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The Sections of Acute Care & Trauma Surgery and Surgical Critical Care, in partnership with Boston University School of Medicine, conducts cutting-edge research on trauma interventions focusing on wound repair and healing, gene regulation after injury and mechanical ventilator impact on traumatic brain injury as well as many other areas of interest. The sections have presented and published at national and international scientific forums.

Clinical and laboratory research has always been a cornerstone of the Boston Medical Center Trauma Program and each year the research activities of the department are highlighted at an annual symposium where resident research studies are challenged, critiqued and disseminated.


About the Study

The Acute Lung Injury Ventilator Evaluation (ALIVE) Trial is a multi-center research study to identify optimal treatment methods for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). These syndromes are associated with 30-40% mortality with our current standard of care and are responsible for approximately 75,000 deaths in the US yearly. Mechanical ventilation techniques remain the only accepted treatment therapy for patients with these injuries, but ventilation is also associated with segmental lung collapse, increased time on a ventilator and increased incidence of pneumonia. The long-term goal is to improve the health outcomes of patients with acute lung injury and acute respiratory distress syndrome and gain a better understanding of its pathogenesis, prevention and treatment.

Subjects from 8 clinical sites will be entered into the study. Approximately 96 subjects will receive 6 hours each of ARDSNet and APRV ventilator modes. Markers inflammation and injury measured during the two time periods will be compared. This study is funded by the National Trauma Institute.

For more information about this study, please contact Lauren Howard via email or call 617.414.8013.

Download Trial Documents

ALIVE Trial SAE Coordinator

If a subject at your site experiences an SAE that must be reported to the SAE Coordinator, please dial 617.638.5795 and enter pager #4788. This pager is covered 24-hours a day, 7 days a week.

Participating Centers with Principal Investigators

  • Jeremy Cannon, MD, Brooke Army Medical Center
  • Peter Burke, MD, Boston Medical Center
  • David King, MD, Massachusetts General Hospital
  • Timothy Emhoff, MD, University of Massachusetts Memorial Medical Center
  • Matthew Lissauer, MD, University of Maryland Medical Center
  • Daniel Holena, MD, Hospital of the University of Pennsylvania
  • Stephen Cohn, MD, University of Texas Health Center
  • Joseph Cuschieri, MD, Harborview Medical Center at the University of Washington