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ARUBA study

ARUBA Study: A Randomized Multi-center Clinical Trial of Un-ruptured Brain AVMs


An arteriovenous malformation (AVM) is a tangled bundle of abnormal arteries and veins that are directly connected to each other. In general, arteries carry fresh oxygen-filled blood from the heart and distribute it through fine and finer vessels (arterioles and capillaries) to all parts of the body to nourish the tissue. Veins bring the "used" blood back to the heart. In the case of an AVM, there is an absence of capillaries and the blood goes directly from an artery into a vein. The main risk of an AVM in the brain is the risk of sudden bleeding if the AVM ruptures. Symptoms might resemble a stroke but also may include headaches or seizures. An AVM that has not bled is called an un-ruptured AVM.


Mohr JP, Parides MK, Staph C et al. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomized trial. Lancet 2014;383(9917):614-621.